Valerie Arboleda, M.D., Ph.D.

Assistant Professor  

Bio

Dr. Arboleda is an Assistant Professor of Pathology & Lab Medicine, Human Genetics, and Computational Medicine at the David Geffen School of Medicine at UCLA. Dr. Arboleda graduated from the UCLA Medical Student Training Program (MSTP) with a Ph.D in Human Genetics and an MD in 2014. She went on to complete residency training in clinical pathology with an emphasis in molecular genetic pathology in the Department of Pathology and Laboratory Medicine at UCLA. She joined the faculty of the David Geffen School of Medicine at UCLA in 2018.  Dr. Arboleda was awarded the NIH Director’s Early Independence Award (DP5), which provides independent research funding to young scientists to start independent research careers without formal post-doctoral training. She was the recipient of the Daljit S. and Elaine Sarkaria Fellowship, and the Charles J. Epstein Pre-doctoral Award for Excellence in Human Genetics Research from ASHG, and was selected for the John H. Walsh Young Investigator Award in 2021.

Dr. Arboleda’s research program studies the causal relationships between genetic variation and human disease from the clinical perspective. A major challenge in genomics is how to interpret DNA variation in the context of disease diagnosis, therapeutics, and prognosis. Interpreting how the DNA code influences human disease is an important next step in Genomic Medicine. The lab leverages a bidirectional approach, starting from genes to phenotypes and then exploring clinical phenotypes within the electronic health record and identifying novel genetic associations. Arboleda's projects use patient derived samples to develop rare-disease model systems and functional genomic approaches (RNA-seq, ATAC-seq ChIP-seq, methylation-seq) to understand molecular dysregulation cause by these mutations and identify drug targets.  Her lab is also part of larger scale collaborations to explore the role of genetic ancestry with disease risk and looking at the shared genetic basis of monogenic and complex diseases.

Arboleda's Lab
@ArboledaVal