Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors | Bogdan Pasaniuc

Timothy S.Chang M.D., Ph.D., YiDing M.S., Malika K.Freund Ph.D., RuthJohnson B.S., TommerSchwarz B.S., Julie M.Yabu M.D., M.S., ChadHazlett Ph.D., Jeffrey N.Chiang Ph.D, David A.Wulf M.S., UCLA Precision Health Data Discovery Repository Working Group Daniel H.Geschwind M.D., Ph.D., Manish J.Butte M.D., Ph.D., BogdanPasaniuc Ph.D.

Friday, February 12, 2021
Published in iScience

Abstract

Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors for HL have relied on county-level data. We investigated COVID-19 risk factors in HL using individual-level, electronic health records in a Los Angeles health system between March 9 and August 31, 2020. Of 9,287 HL tested for SARS-CoV-2, 562 were positive. HL constituted an increasing percentage of all COVID-19 positive individuals as disease severity escalated. Multiple risk factors identified in Non-Hispanic/Latinx whites (NHL-W), like renal disease, also conveyed risk in HL. Pre-existing nonrheumatic mitral valve disorder was a risk factor to HL hospitalization but not for NHL-W COVID-19 or HL influenza hospitalization, suggesting it may be a specific HL COVID-19 risk. Admission laboratory values also suggested that HL presented with a greater inflammatory response. COVID-19 risk factors for HL can help guide equitable government policies and identify at-risk populations.