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Machine learning tool identifies rare, undiagnosed immune disorders through patients’ electronic health records

By Kevin McClanahan

Researchers say a machine learning tool can identify many patients with rare, undiagnosed diseases years earlier, potentially improving outcomes and reducing cost and morbidity. The findings, led by researchers at UCLA Health, are described in Science Translational Medicine.

MSCR Alumnus Recognized for Advancing Diversity in Healthcare

Dr. Bruce Ovbiagele, associate dean and professor of neurology at the University of California, San Francisco (UCSF), has been honored with the prestigious W. Lester Henry Award for Diversity, Equity, and Inclusion by the American College of Physicians. This esteemed accolade is a testament to Dr. Ovbiagele's unwavering commitment to fostering diversity and equity within the healthcare landscape.

Professor Ken Lange honored at annual symposium

UCLA’s departments of Computational Medicine and Human Genetics, with support from NIH, held the fourth Lange Symposium on January 26th, 2024. The topic for this year’s symposium was Computational and Statistical Genomics. This annual event celebrates the impact of Dr. Lange’s research, mentorship, and teaching throughout an illustrious career spanning more than four decades. It featured scientific talks by some of Dr. Lange’s esteemed colleagues and former trainees:

Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries

Biobanks that collect deep phenotypic and genomic data across many individuals have emerged as a key resource in human genetics. However, phenotypes in biobanks are often missing across many individuals, limiting their utility. We propose AutoComplete, a deep learning-based imputation method to impute or ‘fill-in’ missing phenotypes in population-scale biobank datasets. When applied to collections of phenotypes measured across ~300,000 individuals from the UK Biobank, AutoComplete substantially improved imputation accuracy over existing methods.

Biomedical Data Science for Precision Health Equity Trainees Attend National Conference

Three PhD students supported by the Biomedical Data Science for Precision Health Equity training program, along with PI Professor Bogdan Pasaniuc (Computational Medicine) and Professor Alex Bui (Radiological Sciences, Bioengineering), attended the NLM T15 Training Conference, held at Stanford in June. All T-15 institutions from across the country participated in the three-day meeting, which featured a keynote address from Dr.

UCLA biobank study reveals disease risk, health care use among LA’s diverse population

A new study of UCLA Health’s large genetic biobank is giving researchers new insights into the disease risks faced by the region’s diverse communities and their access to health care. The effort, published in Nature Medicine, may prove useful in developing personalized medicine and treatment approaches to groups often overlooked by the medical system.

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